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Women's Health Science Journal Research Article 15 min read

Antioxidant Therapy in Pregnancy: Enhancing Maternal-Infant Well-being through Redox Balance

Obeagu EI* and Obeagu GU*
* Corresponding author
ISSN: 2639-2526  10.23880/whsj-16000219  Received: March 06, 2024  Published: March 19, 2024
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Keywords
Antioxidant Therapy Pregnancy Maternal Health Fetal Development Oxidative Stress Placenta Free Radicals Reactive Oxygen Species
Abstract

Pregnancy is a complex physiological state characterized by dynamic changes in the maternal body to support fetal growth and development. However, this intricate process can also lead to increased oxidative stress, characterized by an imbalance between the productions of reactive oxygen species (ROS) and the body’s ability to neutralize them. Excessive oxidative stress during pregnancy has been linked to various gestational complications, including preeclampsia, gestational diabetes, and preterm birth, highlighting the need for interventions to enhance maternal and fetal well-being. Antioxidant therapy has emerged as a promising approach to counteract oxidative stress and mitigate its adverse effects during pregnancy. This review explores the current state of knowledge regarding the role of antioxidants in pregnancy, focusing on their potential benefits in improving maternal health and optimizing fetal development.

Introduction

Pregnancy, a remarkable and complex physiological journey, involves dynamic adaptations in the maternal body to nurture and sustain fetal growth [1, 2]. These intricate processes, orchestrated by a myriad of hormonal and metabolic changes, create a delicate balance that is pivotal for the well-being of both the mother and the developing fetus. Central to this equilibrium is the maintenance of redox balance, ensuring that reactive oxygen species (ROS) are regulated within a physiological range. However, the increased metabolic demands of pregnancy and the extensive remodeling of maternal tissues create an environment where the generation of ROS can surpass the body’s antioxidant defense mechanisms, leading to oxidative stress [3, 4, 5, 6, 7, 8, 9, 10, 11, 12]. Oxidative stress during pregnancy is a double-edged sword, as it plays a crucial role in various physiological processes such as embryonic development, implantation, and placental function. Yet, when this delicate balance is disrupted, oxidative stress becomes a contributing factor to gestational complications. Preeclampsia, gestational diabetes, and preterm birth are among the serious conditions linked to an overabunda12nce of ROS. As our understanding of the intricate molecular pathways involved in these processes grows, so does the interest in interventions aimed at modulating oxidative stress to optimize maternal and fetal outcomes[13, 14, 15, 16, 17]. The placenta, acting as the vital interface between the maternal and fetal circulations, is particularly susceptible to oxidative damage. Its compromised function can have far-reaching consequences for fetal development. Antioxidant defense mechanisms, comprising enzymatic and non-enzymatic systems, are the body’s frontline against oxidative stress [18, 19, 20, 21, 22].

Sources of Oxidative Stress in Pregnancy

The powerhouse of the cell, mitochondria, is a key player in energy production and a significant source of reactive oxygen species (ROS). During pregnancy, increased metabolic demands can lead to mitochondrial dysfunction, disrupting the electron transport chain and promoting ROS generation. The delicate balance required for efficient energy production becomes susceptible to oxidative stress, impacting cellular function and contributing to gestational complications. Inflammatory processes, integral to the immune response, are heightened during pregnancy to support fetal development and protect against infections. However, an exaggerated or prolonged inflammatory response can lead to an overproduction of ROS. In conditions like preeclampsia and infections, the inflammatory cascade may become dysregulated, fostering oxidative stress and jeopardizing the delicate harmony required for successful gestation [23, 24, 25, 26, 27].

Environmental stressors, including exposure to pollutants, cigarette smoke, and certain medications, can introduce exogenous sources of oxidative stress during pregnancy. Xenobiotic and environmental toxins can initiate ROS production, placing additional strain on the maternal antioxidant defense systems. Understanding and mitigating these external contributors is crucial in preventing oxidative stress-related complications. Pregnancy induces significant hormonal fluctuations, including elevated levels of estrogen, progesterone, and human chorionic gonadotropin (hCG). While essential for maintaining pregnancy, these hormonal shifts can also contribute to oxidative stress. For instance, elevated estrogen levels have been associated with increased ROS production, potentially impacting placental function and vascular health. Iron is vital for fetal development, but an excess can lead to iron overload and subsequent oxidative stress. The iron content in the maternal diet, coupled with increased iron absorption during pregnancy, poses a potential risk. Uncontrolled iron levels can catalyze the formation of free radicals through Fenton reactions, disrupting cellular homeostasis. The placenta, a pivotal organ in pregnancy, is vulnerable to oxidative damage due to its role in nutrient exchange and hormone production. Inadequate perfusion, ischemia-reperfusion events, and alterations in placental blood flow can instigate oxidative stress, negatively impacting fetal development and contributing to conditions such as intrauterine growth restriction (IUGR). Advanced maternal age and certain lifestyle choices, such as a sedentary lifestyle, poor dietary habits, and obesity, can exacerbate oxidative stress. Aging is associated with a decline in antioxidant defense mechanisms, rendering older mothers more susceptible to oxidative damage. Lifestyle factors further influence the redox balance, emphasizing the importance of holistic maternal health in preventing gestational complications [27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47].

Antioxidant Defense Mechanisms

SOD is a pivotal enzyme that catalyzes the dismutation of superoxide radicals into hydrogen peroxide and molecular oxygen. This process constitutes the first line of defense against the superoxide radicals generated during various cellular activities. In pregnancy, SOD plays a crucial role in mitigating oxidative stress, especially in the placenta, where its activity is elevated to protect against potential damage. Operating primarily in peroxisomes, catalase converts hydrogen peroxide into water and oxygen, preventing the accumulation of this reactive species. In the context of pregnancy, catalase is essential for maintaining redox balance within cells and tissues, safeguarding against oxidative damage to vital structures like the placenta. GPx is a selenium- dependent enzyme responsible for detoxifying hydrogen peroxide and lipid hydroperoxides by utilizing reduced glutathione. In pregnancy, GPx is critical for protecting maternal and fetal tissues from oxidative stress, and its activity is often up regulated to counterbalance the increased production of free radicals. As a water-soluble antioxidant, vitamin C scavenges free radicals and regenerates other antioxidants, such as vitamin E. During pregnancy, vitamin C contributes to maintaining the integrity of the amniotic fluid, placental tissues, and fetal membranes, providing a defense against oxidative stress-related complications [48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62].

Vitamin E, a fat-soluble antioxidant, protects cell membranes by intercepting lipid peroxidation chain reactions. In pregnancy, vitamin E is crucial for preventing oxidative damage to fetal cells and membranes, and its levels are intricately regulated to meet the heightened antioxidant demand. Known as the “master antioxidant,” glutathione is a tripeptide that acts as a co-factor for various enzymatic antioxidant reactions. In pregnancy, maintaining optimal levels of glutathione is vital for neutralizing free radicals, supporting placental function, and protecting the developing fetus from oxidative stress-related harm. Selenium is an essential trace element incorporated into selenoproteins, including GPx. Its role as a cofactor for GPx underscores its significance in antioxidant defense mechanisms during pregnancy. Adequate selenium levels are crucial for ensuring the efficacy of GPx in neutralizing reactive oxygen species. Coenzyme Q10 is a lipid-soluble antioxidant that participates in mitochondrial electron transport and serves as a potent scavenger of free radicals. During pregnancy, Coenzyme Q10 plays a crucial role in maintaining mitochondrial function, reducing oxidative stress, and supporting energy production essential for fetal development [63, 64, 65, 66, 67, 68].

Conclusion

The accumulating body of evidence supports the potential benefits of antioxidant therapy in pregnancy, offering a promising avenue for enhancing maternal and infant well-being. The intricate balance between oxidative stress and antioxidant defense mechanisms during gestation underscores the delicate nature of this physiological state. Clinical studies have provided compelling insights into the positive effects of antioxidant supplementation across various aspects of pregnancy, from preventing hypertensive disorders like preeclampsia to mitigating the risk of gestational diabetes and preterm birth. The prevention of preeclampsia, a condition intricately linked to oxidative stress, stands out as a significant achievement in antioxidant research. Trials demonstrating reduced blood pressure, improved vascular function, and decreased proteinuria highlight the potential for antioxidants to address the complexities of this hypertensive disorder unique to pregnancy. Furthermore, the positive impact of antioxidants on gestational diabetes management showcases their role in optimizing glucose metabolism, thereby contributing to improved maternal and fetal outcomes.

Antioxidant therapy has also shown promise in reducing the risk of preterm birth, a critical factor influencing neonatal health. Improved fetal growth parameters and the potential neurodevelopmental benefits observed in supplemented pregnancies further emphasize the far-reaching implications of antioxidant interventions. Moreover, the mitigation of oxidative stress-related complications, including placental abruption and intrauterine inflammation, underscores the protective effects that antioxidants may offer during gestation.

References

  1. Avery MD (2013) Supporting a physiologic approach to pregnancy and birth: A practical guide. John Wiley & Sons.
  2. Blackburn S (2016) Maternal, Fetal, & neonatal physiology: a clinical perspective. 5th Edition (Edn.), Elsevier Health Sciences.
  3. Obeagu EI, Agreen FC (2023) Anaemia among pregnant women: A review of African pregnant teenagers. J Pub Health Nutri 6 (1): 138.
  4. Obeagu EI, Ezimah AC, Obeagu GU (2016) Erythropoietin in the anaemias of pregnancy: a review. Int J Curr Res Chem Pharm Sci 3(3): 10-18.
  5. Obeagu EI, Adepoju OJ, Okafor CJ, Obeagu GU, Ibekwe AM, et al. (2021) Assessment of Haematological Changes in Pregnant Women of Ido, Ondo State, Nigeria. J Res Med Dent Sci 9(4): 145-148.
  6. Obeagu EI, Obeagu GU (2023) Sickle Cell Anaemia in Pregnancy: A Review. International Research in Medical and Health Sciences 6(2): 10-13.
  7. Jakheng SP, Obeagu EI (2022) Seroprevalence of human immunodeficiency virus based on demographic and risk factors among pregnant women attending clinics in Zaria Metropolis, Nigeria. J Pub Health Nutri 5(6): 127.
  8. Obeagu EI, Obeagu GU, Obiezu J, Ezeonwumelu C, Alum EU, et al. (2023) Antioxidants and Pregnancy: Impact on Maternal and Fetal Health. Applied Sciences (NIJBAS) 4(1): 17-25.
  9. Obeagu EI, Bunu UO, Obeagu GU, Habimana JB (2023) Antioxidants in the management of sickle cell anaemia: an area to be exploited for the wellbeing of the patients. International Research in Medical and Health Sciences 6(4): 12-17.
  10. Obeagu EI, Ubosi NI, Uzoma G (2023) Antioxidant Supplementation in Pregnancy: Effects on Maternal and Infant Health. Int J Adv Multidiscip Res 10(11): 60-70.
  11. Obeagu EI, Obeagu GU (2018) Utilization of Antioxidants in the management of diabetes mellitus patients. J Diabetes Clin Prac 1(1): 102.
  12. Nwosu DC, Obeagu EI, Nkwocha BC, Nwanna CA, Nwanjo HU, et al. (2016) Change in Lipid Peroxidation Marker (MDA) and Non enzymatic Antioxidants (VIT C & E) in HIV Seropositive Children in an Urban Community of Abia State. Nigeria. J Bio Innov 5(1): 24-30.
  13. Nwosu DC, Obeagu EI, Ezenwuba C, Agu GC, Amah H, et al. (2016) Antioxidant status of children with Plasmodium falciparum malaria in Owerri municipal council of Imo state. Int J Curr Res Chem Pharm Sci 3(8): 40-46.
  14. Ezimah UA, Obeagu EI, Ezimah CO, Ezimah A, Nto NJ (2016) Diarrhoeal diseases of acquired immunodeficiency syndrome stimulates more depletion of total antioxidant status. Int J Adv Multidiscip Res 3(4): 23-25.
  15. Aloh GS, Obeagu EI, Okoroiwu IL, Odo CE, Chibunna OM, et al. (2015) Antioxidant-Mediated Heinz Bodies Levels of Sickle Erythrocytes under Drug-Induced Oxidative Stress. European Journal of Biomedical and Pharmaceutical sciences 2(1): 502-507.
  16. Alum EU, Aja W, Ugwu OP, Obeagu EI, Okon MB (2023) Assessment of vitamin composition of ethanol leaf and seed extracts of datura stramonium. Avicenna J Med Biochem 11(1): 92-97.
  17. Alum EU, Inya JE, Ugwu OP, Obeagu EI, Aloke C, et al. (2023) Ethanolic leaf extract of Datura stramonium attenuates methotrexate-induced biochemical alterations in Wistar Albino rats. RPS Pharmacy and Pharmacology Reports 2(1): rqac011.
  18. Obeagu EI, Obeagu GU, Chukwueze CM, Ikpenwa JN, Ramos GF (2022) Evaluation of Protein C, Protein S and Fibrinogen of Pregnant Women with Malaria in Owerri Metropolis. Madonna University journal of Medicine and Health Sciences 2(2): 1-9.
  19. Obeagu EI, Ikpenwa JN, Chukwueze CM, Obeagu GU (2022) Evaluation of protein C, protein S and fibrinogen of pregnant women in Owerri Metropolis. Madonna University Journal of Medicine and Health Sciences 2(1): 292-298.
  20. Obeagu EI, Obeagu GU, Adepoju OJ (2022) Evaluation of haematological parameters of pregnant women based on age groups in Olorunsogo road area of Ido, Ondo state. J Bio Innov 11(3): 936-941.
  21. Obeagu EI (2022) An update on utilization of antenatal care among pregnant Women in Nigeria. Int J Curr Res Chem Pharm Sci 9(9): 21-26
  22. Okoroiwu IL, Obeagu EI, Obeagu GU (2022) Determination of clot retraction in preganant women attending antenatal clinic in federal medical centre Owerri, Nigeria. Madonna University Journal of Medicine and Health Sciences 2(2): 91-97.
  23. Nwakuilite A, Nwanjo HU, Nwosu DC, Obeagu EI (2020) Evaluation of Enzyme Antioxidants in Streptozocin Induced Diabetic Rats Treated with Moringa Oleifera Leaf Powder. European Journal of Biomedical 7(11): 285-288.
  24. Ifeanyi OE (2018) A review on free radicals and antioxidants. Int J Curr Res Med Sci 4(2): 123-133.
  25. Akinpelu M, Gamade SM, Akinbo F, Adeniyi TD, Elizebeth AF, et al. (2023) Histopathological and Biochemical Effect of Vitamin C and D on Phosphine-Induced Hepatotoxicity in Wistar Rats. Asian Journal of Dental and Health Sciences 3(2): 18-22.
  26. Nwakulite A, Obeagu EI, Eze R, Ugochi VE, Vincent CC, et al. (2021) Estimation of Serum Glutathione Peroxidase in Streptozotocin Induced Diabetic Rat Treated with Bitter Leaf Extract. Journal of Pharmaceutical Research International 33(30B): 200-206.
  27. Ifeanyi OE, Stella EI, Favour AA (2018) Antioxidants in the Management of Sickle Cell Anaemia. Int J Hematol Blo Dis 3(2): 1-2.
  28. Obeagu EI, Hassan AO, Adepoju OJ, Obeagu GU, Okafor CJ (2021) Evaluation of Changes in Haematological Parameters of Pregnant Women Based on Gestational Age at Olorunsogo Road Area of Ido, Ondo State. Nigeria. Journal of Research in Medical and Dental Science 9(12): 462-464.
  29. Anyiam AF, Obeagu EI, Obi E, Omosigho PO, Irondi EA, et al. (2022) ABO blood groups and gestational diabetes among pregnant women attending University of Ilorin Teaching Hospital, Kwara State, Nigeria. International Journal of Research and Reports in Hematology 5(2): 159-167.
  30. Obeagu EI (2023) Gestational Thrombocytopaenia. J Gynecol Women’s Health 25(3): 556163.Jakheng SP, Obeagu EI, Abdullahi IO, Jakheng EW, Chukwueze CM, et al. (2022) Distribution Rate of Chlamydial Infection According to Demographic Factors among Pregnant Women Attending Clinics in Zaria Metropolis, Kaduna State, Nigeria. South Asian Journal of Research in Microbiology 13(2): 26-31.
  31. Obeagu EI, Ogbonna US, Nwachukwu AC, Ochiabuto O, Enweani IB, et al. (2021) Prevalence of Malaria with Anaemia and HIV status in women of reproductive age in Onitsha, Nigeria. Journal of Pharmaceutical Research International 33(4): 10-19.
  32. Obeagu EI, Abdirahman BF, Bunu UO, Obeagu GU (2023) Obsterics characteristics that effect the newborn outcomes. Int. J. Adv. Res. Biol. Sci 10(3): 134-143.
  33. Obeagu EI, Ogunnaya FU (2023) Pregnancy Induced Hematological Changes: A Key to Maternal and Child Health. European Journal of Biomedical 10(8): 42-43.
  34. Okamgba OC, Nwosu DC, Nwobodo EI, Agu GC, Obeagu EI, et al. (2017) Iron Status of Pregnant and Post-Partum Women with Malaria Parasitaemia in Aba Abia State, Nigeria. Annals of Clinical and Laboratory Research 5(4): 206.
  35. Eze RI, Obeagu EI, Edet FN (2021) Frequency of Rh Antigen C and c among pregnant women in Sub-Urban area in Eastern Nigeria. Madonna Uni J Med Health Sci 1(1): 19-30.
  36. Obeagu EI, Ofodile AC, Okwuanaso CB (2023) A review of urinary tract infections in pregnant women: Risks factors. J Pub Health Nutri 6(1): 137.
  37. Obeagu EI, Obeagu GU, Musiimenta E (2023) Postpartum haemorrhage among pregnant women: Update on risks factors. Int J Curr Res Med Sci 9(2): 14-17.
  38. Obeagu EI, Obeagu GU, Ogunnaya FU (2023) Deep vein thrombosis in pregnancy: A review of prevalence and risk factors. Int J Curr Res Chem Pharm Sci 10(8): 14-21.
  39. Okorie HM, Obeagu EI, Eze EN, Jeremiah ZA (2018) Assessment of some haematological parameters in malaria infected pregnant women in Imo state Nigeria. Int J Curr Res Biol Med 3(9): 1-14.
  40. Onyenweaku FC, Amah HC, Obeagu EI, Nwandikor UU, Onwuasoanya UF (2017) Prevalence of asymptomatic bacteriuria and its antibiotic susceptibility pattern in pregnant women attending private ante natal clinics in Umuahia Metropolitan. Int J Curr Res Biol Med 2(2): 13- 23.
  41. Okoroiwu IL, Chinedu-Madu JU, Obeagu EI, Vincent CC, Ochiabuto OM, et al. (2021) Evaluation of Iron Status, Haemoglobin and Protein Levels of Pregnant Women in Owerri Metropolis. Journal of Pharmaceutical Research International 33(27A): 36-43.
  42. Obeagu EI, Njar VE, Obeagu GU (2023) Infertility: Prevalence and Consequences. Int. J. Curr. Res. Chem. Pharm. Sci 10(7): 43-50.
  43. Emeka-Obi OR, Ibeh NC, Obeagu EI, Okorie HM (2021) Evaluation of levels of some inflammatory cytokines in preeclamptic women in owerri. Journal of Pharmaceutical Research International 33(42A): 53-65.
  44. Obeagu EI, Faduma MH, Uzoma G (2023) Ectopic Pregnancy: A Review. Int. J. Curr. Res. Chem. Pharm. Sci 10(4): 40-44.
  45. Obeagu EI, Gamade SM, Obeagu GU (2023) The roles of Neutrophils in pregnancy. Int. J. Curr. Res. Med. Sci 9(5): 31-35.
  46. Eze R, Obeagu EI, Nwakulite A, Okoroiwu IL, Vincent CC, et al. (2021) Evaluation of Copper Status and Some Red Cell Parameters of Pregnant Women in Enugu State, South Eastern Nigeria. Journal of Pharmaceutical Research International 33(30A): 67-71.
  47. Obeagu EI, Obeagu GU (2023) Molar Pregnancy: Update of prevalence and risk factors. Int. J. Curr. Res. Med. Sci 9(7): 25-28.
  48. Obeagu EI, Bunu UO (2023) Factors that influence unmet need for family planning. International Journal of Current Research in Biology and Medicine 8(1): 23-27.
  49. Ibebuike JE, Ojie CA, Nwokike GI, Obeagu EI, Nwosu DC, et al. (2017) Barriers to utilization of maternal health services in southern senatorial district of Cross Rivers state, Nigeria. International Journal of Advanced Multidisciplinary Research 4(8): 1-9.
  50. Emannuel G, Martin O, Peter OS, Obeagu EI, Daniel K (2023) Factors Influencing Early Neonatal Adverse Outcomes among Women with HIV with Post Dated Pregnancies Delivering at Kampala International University Teaching Hospital, Uganda. Asian Journal of Pregnancy and Childbirth 6(1): 203-211.
  51. Okorie HM, Obeagu EI, Eze EN, Jeremiah ZA (2018) Assessment of coagulation parameters in malaria infected pregnant women in Imo state, Nigeria. International Journal of Current Research in Medical Sciences 4(9): 41-49.
  52. Obeagu EI, Obeagu GU (2023) Postpartum Haemorrhage among Women delivering through spontaneous Vaginal Delivery: Prevalence and risk factors. Int J Curr Res Chem Pharm Sci 10(8): 22-26.
  53. Obeagu E, Eze RI, Obeagu EI, Nnatuanya IN, Dara EC (2022) Zinc Level in Apparently Pregnant Women in Urban Area. Madonna University journal of Medicine and Health Sciences 2(1): 134-148.
  54. Ogomaka IA, Obeagu EI (2021) Malaria in Pregnancy Amidst Possession of Insecticide Treated Bed Nets (ITNs) in Orlu LGA of Imo State, Nigeria. Journal of Pharmaceutical Research International 33(41B): 380- 386.
  55. Obeagu EI, Ogunnaya FU, Obeagu GU, Ndidi AC (2023) Sickle Cell Anaemia: A Gestational Enigma. Migration 17: 18.
  56. Ifeanyi OE, Uzoma OG (2018) A review on erythropietin in pregnancy. Journal of Gynecol & Womens Health 8(3): 1-4.
  57. Ifeanyi OE (2018) A review on pregnancy and haematology. Int J Curr Res Biol Med 3(5): 26-28.
  58. Nwosu DC, Nwanjo HU, Obeagu EI, Ibebuike JE, Ezeama MC, et al. (2015) Changes in liver enzymes and lipid profile of pregnant women with malaria in Owerri, Nigeria. International Journal of Current Research and Academic Review 3(5): 376-383.
  59. Ibebuike JE, Ojie CA, Nwokike GI, Obeagu EI, Nwosu DC (2017) Factors that influence women’s utilization of primary health care services in Calabar Cros river state, Nigeria. Int J Curr Res Chem Pharm. Sci 4(7): 28-33.
  60. Eze R, Ezeah GA, Obeagu EI, Omeje C, Nwakulite A (2021) Evaluation of iron status and some haematological parameters of pregnant women in Enugu, South Eastern Nigeria. World Journal of Pharmaceutical and Medical Research 7(5): 251-254.
  61. Elemchukwu Q, Obeagu EI, Ochei KC (2014) Prevalence of Anaemia among Pregnant Women in Braithwaite Memorial Specialist Hospital (BMSH) Port Harcourt. IOSR Journal of Pharmacy and Biological Sciences 9(5): 59-64.
  62. Akandinda M, Obeagu EI, Katonera MT (2022) Non Governmental Organizations and Women’s Health Empowerment in Uganda: A Review. Asian Research Journal of Gynaecology and Obstetrics 5(1): 263-267.
  63. Vidya S, Kumar S, Jakheng SPE, Obeagu EI, Jakheng EW, et al. (2022) Occurrence of Chlamydial Infection Based on Clinical Symptoms and Clinical History among Pregnant Women Attending Clinics in Zaria Metropolis, Kaduna State, Nigeria. International Journal of Research and Reports in Gynaecology 5(1): 222-229.
  64. Gamde MS, Obeagu EI (2023) Iron Deficiency Anaemia: Enemical to Pregnancy. European Journal of Biomedical 10(9): 272-275.
  65. Emeka-Obi OR, Ibeh NC, Obeagu EI, Okorie HM (2021) Evaluation of levels of some inflammatory cytokines in preeclamptic women in owerri. Journal of Pharmaceutical Research International 33(42A): 53-65.
  66. Emeka-Obi OR, Ibeh NC, Obeagu EI, Okorie HM (2021) Studies of Some Haemostatic Variables in Preeclamptic Women in Owerri, Imo State, Nigeria. Journal of Pharmaceutical Research International. 33(42B): 39-48.
  67. Obeagu EI, Obeagu GU (2023) Postpartum haemorrhage among women delivering through spontaneous vaginal delivery: Prevalence and risk factors. Int J Curr Res Chem Pharm Sci 10(8): 22-26.
  68. Obeagu EI, Obeagu GU (2023) Sickle Cell Anaemia in Pregnancy: A Review. International Research in Medical and Health Sciences 6(2): 10-13.
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@article{obeagu2024,
  title   = {Antioxidant Therapy in Pregnancy: Enhancing Maternal-Infant
Well-being through Redox Balance},
  author  = {Obeagu EI* and Obeagu GU},
  journal = {Women\'s Health Science Journal},
  year    = {2024},
  volume  = {8},
  number  = {1},
  doi     = {10.23880/whsj-16000219}
}
Obeagu EI* and Obeagu GU (2024). Antioxidant Therapy in Pregnancy: Enhancing Maternal-Infant
Well-being through Redox Balance. Women's Health Science Journal, 8(1). https://doi.org/10.23880/whsj-16000219
TY  - JOUR
TI  - Antioxidant Therapy in Pregnancy: Enhancing Maternal-Infant
Well-being through Redox Balance
AU  - Obeagu EI* and Obeagu GU
JO  - Women's Health Science Journal
PY  - 2024
VL  - 8
IS  - 1
DO  - 10.23880/whsj-16000219
ER  -