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Annals of Immunology and Immunotherapy

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Mohammed Rachidi

Mohammed Rachidi

Editorial Board Member
University Paris Denis Diderot France Member since 2018

Biography

Mohammed Rachidi received his PhD/ Doctorate Degree in Human & Molecular Genetics (with High Honors) at the prestigious ''Pasteur Institute'' (Paris, France), in the Department of Molecular & Cellular Genetics Headed by the Professor François Jacob (Nobel Prize in Physiology/Medicine), where he studied the Cellular & Molecular Mechanisms underlying Brain & Visual System development, CaMKinases & Biological Clock Functions in Drosophila. He extended these Molecular Genetics works to Functional Genomics at Pasteur Institute and Center National of Research Scientific and played key fundamental roles in different collaborative research projects with prestigious laboratories in Europe, Japan & United States. Remarkably, he collaborated with the Professor Michael Rosbash (Nobel Prize in Physiology/Medicine 2017) in the Molecular Mechanisms of 2 genes involved in Circadian Clock. He published with Professor Rosbash this important work in the EMBO Journal Entitled: ''A New Gene Encoding a Putative Transcritpion Factor Regulated by the Drosophila Circadian Clock''. Postdoctoral training & Assistant Professor with Professor Nicole Le Douarin at the prestigious ''College De France'' & Institute of Cellular & Molecular Embryology (Paris), he studied some Chicken & Xenopus molecules acting in Bone Morphogenetic Protein BMP signaling pathways and identified their Mouse & Human Homologs involved in Differentiation of specific domains of Neuronal Progenitors, cerebellum development & Joubert syndrome. These experiences of Dr. Rachidi were extended to Human Molecular Genetics of Down syndrome (DS), to Molecular & Cellular Mechanisms underlying Brain Morphogenesis of Trisomic & Transgenic Mouse Models of DS and numerous stages of Embryonic & Fetal DS patients to elucidate the Neurogenetic Basis of Functional Alterations Associated with Mental Retardation. Director of Research in Human Molecular Genetics at Faculty of Medicine of University Paris 5 (France), He realized numerous ''Discoveries and Innovations'' to name a few: (1) Discovery of Quantitative Assessment of Gene Expression (QAGE) as New Method in situ detecting Differential Overexpression of Candidate Genes for Mental Retardation in Down syndrome Brain Regions & for Other Diseases caused by Regionalized Quantitative Transcriptional Variations for Greater Interpretation of Functional Processes Driving Gene Expression. (2) Discovery of New Cerebellar & Cerebral Phenotypes in Transgenic mouse in vivo Library of Human Down syndrome Critical Region. (3) Discovery of a Novel Light Microscopy Technology as Powerful Tool in Developmental Biology & Biomedical & Neuroscience Research. (4) Discovery of the First Proposed Model of Molecular & Cellular Mechanism Elucidating Neurogenetic & Neurocognitive Basis of Functional Impairments Associated with Mental Retardation in Down syndrome. Dr. Rachidi published numerous Articles in highly prestigious international journals with High Impact Factor & Authored numerous Chapters & Books. He has been honored worldwide as Invited Distinguished Speaker, Chairman or Invited Honourable Organizing Committee Member in numerous International Conferences in Europe, USA & Asia. Dr. Rachidi received numerous Awards, Honors and he is an Editor, Associate Editor, Executive Editor or Editor in Chief in numerous International peer-reviewed Journals

Research Interests

Modern Molecular Genetics Neuroscience Biomedical Research Cellular & Molecular Mechanisms Underlying Brain Morphogenesis Visual System Biological Clock Synaptic Protein Targeting Synaptic Plasticity Camkii & CAMGUK/MAGUK Functional Genomics & Mechanisms Controlling Transposition At Cell Cycle Transcription Protein Translation & Virus-Like Particle Formation Bone Morphogenetic Protein Signaling Pathways Mouse and Human Homeobox Genes Cell Fate Determination and Differentiation

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