Discover Research Beta
Browse peer-reviewed articles from Medwin Publishers' open access journals.
Showing 1–12 of 12 articles
Although the comet assay is now a popular method to assess DNA damage induced by environmental genotoxins at a single cell level, it has not been excluded the criticism that some …
Skin aging progresses due to factors such as aging and UV exposure, with oxidative stress and glycation stress being known to be important contributing factors. Reactive oxygen sp…
Among currently used food dyes, we have reported that four azo dye and three xanthene dyes that were given to mice by single gavage at a low dose (10 or 100 mg/kg) induced DNA dama…
Our study using the comet assay to detect genotoxicity of carcinogens in multiple mouse organs reveled that the correlation between genotoxicity and carcinogenicity on an organ-by-…
It is important to know whether the DNA initial lesions are repaired or derive into chromosome aberration, gene mutation and/or cell death to discuss chemical carcinogenicity. To k…
The genotoxicity of pro-mutagens has been traditionally detected by test procedures with metabolically incompetent cells requiring addition of exogenous activation mixtures, such a…
Although it would be ideal if insulin resistance due to a persistent hyperglycemic state could be prevented by consuming particular foods, to the best of our knowledge, no foods wi…
Heterocyclic amines (HCAs) and β-carbolines, carcinogenic substances, are produced when amino acids and creatine in food react in a high-temperature environment. Some of them are r…
Two types of TK mutants are induced by genotoxic factors; normally growing (NG) TK mutants due to point mutations of targeted TK locus, and slowly growing (SG) mutants due to gros…
In order to investigate the relationship between genotoxicity and peroxisome proliferator-activated receptor (PPAR) agonistic effects, we conducted two kinds of comet assays (cell…
We have shown that comet-positive responses by adducts that are repaired by nucleotide excision repair (NER) and base excision repair (BER) are reduced by α-amanitin (AMN) and enh…
Purpose: Propofol is clinically used for anesthesia and sedation. It remains unclear whether propofol induces human neutrophil apoptosis. We sought to determine the effect of prop…