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Re-Evaluation of the Genotoxicity of Currently Used Food Dyes in Mouse Multiple Organs Via Continuous Administration by Drinking Using the Comet Assay

Among currently used food dyes, we have reported that four azo dye and three xanthene dyes that were given to mice by single gavage at a low dose (10 or 100 mg/kg) induced DNA dama…

How Bulky of Base Adducts can be Responsible for Clastogenicity rather than Mutagenicity?

Two types of TK mutants are induced by genotoxic factors; normally growing (NG) TK mutants due to point mutations of targeted TK locus, and slowly growing (SG) mutants due to gros…

Are Bases Alkylated by Branched Alkylating Agents Removed by Nucleotide Excision Repair or Base Excision Repair?

We have shown that comet-positive responses by adducts that are repaired by nucleotide excision repair (NER) and base excision repair (BER) are reduced by α-amanitin (AMN) and enh…

Is Cell Death Responsible for False Positive Results of In Vivo Comet Assay?

Although the comet assay is now a popular method to assess DNA damage induced by environmental genotoxins at a single cell level, it has not been excluded the criticism that some …

Study of Genotoxicity of Hepatocarcinogens in Multiple Organs in Mice by Feeding and Drinking Using the Comet Assay

Our study using the comet assay to detect genotoxicity of carcinogens in multiple mouse organs reveled that the correlation between genotoxicity and carcinogenicity on an organ-by-…

Comparative Investigation of In Vitro Genotoxicity of Pro-Mutagens Using Human-Derived Hepatoma HepG2 Cells with Human and Rat Liver S9

The genotoxicity of pro-mutagens has been traditionally detected by test procedures with metabolically incompetent cells requiring addition of exogenous activation mixtures, such a…

Relations between Visual Axis and Upper Extremity Motion during Eating in Healthy People: Correspondence of Eye Movement Pattern and Velocity Curve

Aim: Eye-hand coordination that occurs when an object gets closer to the body, as with eating motion, is unclear. we conducted a synchronization analysis of the visual axis and up…

Adocus Kohaku, A New Species of Aquatic Turtle (Testudines: Cryptodira: Adocidae) from the Late Cretaceous of Kuji, Iwate Prefecture, Northeast Japan, with Special References to the Geological Age of the Tamagawa Formation (Kuji Group) LSID urn:lsid:zoobank.org:act:61376EEE-A386-416E-98AE-FF64FE2597A2

A nearly complete shell of the genus Adocus (Adocidae; Pan-Trionychia; Cryptodira; Testudines) was collected from the late Cretaceous (Turonian) Tamagawa Formation of Kuji Group at…