Bone Involvement in Classic and Agressive Kaposi Sarcoma

Admi M; Hassani I; Jellali A; Elhassani A; Lahrach K and Boutayeb F

doi:10.23880/jobd-16000123

Journal of Orthopedics & Bone Disorders Research Article 1 min read

Bone Involvement in Classic and Agressive Kaposi Sarcoma

Admi M^*, Hassani I, Jellali A, Elhassani A, Lahrach K and Boutayeb F

^* Corresponding author

ISSN: 2577-297X 10.23880/jobd-16000123 Received: May 06, 2017 Published: May 29, 2017

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Keywords

Bone Involvement Kaposi Sarcoma proliferation

Abstract

Kaposi sarcoma (KS) is an endothelial proliferation described for the first time by moritz kaposi in 1872. It is commonly associated with human herpes virus 8 (HHV8) and human immunodeficiency virus (HIV). Skin and mucous membranes are the most common sites. Osseous involvement in kaposi sarcoma is rare and occurs either by direct spread of mucocutaneous lesions or through dissemination. There are 4 different variants of KS including : African (endemic) KS, classic KS, acquired immune deficiency syndrome (AIDS)-related (epidemic) KS, and transplantation (or immunosuppression)-associated KS.

Introduction

We report a case of 65-year-old male, presented with a 10-year history pain of the right foot. After 6 years of evolution, it was associated with fistulas. Physical examination revealed lymphoedema of the foot with multiple keratosic plaques and nodules, associated to multiple fistulas in dorsal and plantar aspects of the right foot (Figure 1,2). Standard radiography of the feet revealed a massive osteolysis of the right foot skeleton, there was also a Image Article periosteal reaction of the distal tibia and fibula (Figure 3, 4). A skin lesion biopsy was performed, the histopathologic examination confirmed the diagnosis of KS. HIV and Syphilis serology tests were negative. General examination didn’t reveal other locations. The decision of transtibial amputation was made, immunohistochemistry examination showed a dermal nodular proliferation with few mitoses.

Figure 1: Plantar Aspect of the Right Foot Showing Fistulas with Nodular Plaques.

Figure 2: Dorsal Aspect of the Right Foot Showing Plaques, Nodules and Fistulas.

Figure 3: Standard Radiography of the Right Foot Showing Massive Osteolysis

Figure 4: Periosteal Reaction of Distal Tibia and Fibula

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Bone Involvement in Classic and Agressive Kaposi Sarcoma

Introduction

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