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"Boblique J" ×
IZAB Review Article Oct 1, 2026
Non-Equilibrium Allometric Scaling and Bioenergetic Information Routing: A Comparative Science 4.0 Framework for Cellular Resilience Across Mammalian Phyla
Boblique J*

Classical biological allometry historically formalizes metabolic rate scaling through empirical power laws, most notably Kleiber's law (B proportional to M^(3/4)), yet fails …

Allometric Scaling Kleiber&#039 s Law
IZAB Short Communication Sep 8, 2026
Viscoelastic Coupling of Pulsatile Wall Shear Stress and Endothelial Glycocalyx Mechanotransduction: A Non-Equilibrium Hydrodynamic Model for Microvascular Resilience
Boblique J*

The endothelial glycocalyx layer (EGL) functions as the primary mechanosensitive interface modulating hemodynamic forces at the vascular wall. Under physiological pulsatile flow, …

Endothelial Glycocalyx Layer (EGL) Wall Shear Stress (WSS) Womersley Number
IZAB Editorial Aug 5, 2026
Science 4.0 and the Bio-OS V8 Architecture: Algorithmic Governance for Biological Sovereignty
Boblique J*

Traditional biological frameworks operate primarily within a reactive diagnostic paradigm. This paper presents the finalized architecture of Science 4.0 and its core Biological Op…

Science 4.0 Bio-OS V8 Algorithmic Governance
JENR Editorial Jul 29, 2026
Bio-OS V8 Algorithmic Governance: Industrializing Epigenetic Sustainability in Socio-Technical Ecosystems
Boblique J*

Following our foundational framework on Epigenetic Sustainability (Boblique, 2026), this paper advances the operational deployment of the Bio-OS V8 architecture. While previous mo…

Epigenetic Sustainability Bio-OS V8 Algorithmic Governance
IZAB Research Article Jun 29, 2026
Industrial Standardization of the Bio-OS: Algorithmic Codification of Resilience Engineering Guidelines and Version V8 Architecture
Boblique J*

Purpose: This paper formalizes the transition of Science 4.0 from an empirical tracking framework into an industrialized, scalable Biological Operating System (Bio-OS V8). We esta…

Stress-Epigenetic-Transition Ubiquinol Vectorization Science 4.0
IZAB Mini Review Jun 10, 2026
Mitochondrial Bio-Logistics: Steering Co-Enzyme Q10 and Lycopene Synergies within the Science 4.0 Bio-OS Framework
Boblique J*

Traditional approaches to nutraceutical design and metabolic optimization consistently fail to account for the highly restrictive, non-linear constraints inherent in aging biologi…

Science 4.0 Renal Hydraulics Biological Systems
IZAB Mini Review May 21, 2026
Science 4.0: Comprehensive Architecture of the Biological Operating System (Bio-OS) A Framework for Systemic Resilience and Industrialized Bio-Governance
Boblique J*

This document presents the finalized architecture of Science 4.0, moving beyond theoretical modeling into a functional Biological Operating System (Bio-OS). By treating the human …

Biological Operating System Science 4.0 Systemic Sovereignty
IZAB Mini Review Apr 22, 2026
Clinical Validation of Science 4.0: Flow Steering and Epigenetic Drift Inversion on a 76-Year-Old Hybrid System
Boblique J*

This report documents the high-velocity transition of a complex biological system (76-year-old subject, 70 cc prostatic volume) from a state of congestion to restored fluidic resi…

Biological System Inflammatory Signals Securing Renal Filtration
IZAB Editorial Mar 23, 2026
Science 4.0-Architecture of Cellular Resilience and Living Signal Optimization
Boblique J*

Beyond Reactive Biology Contemporary science operates primarily within a reactive framework, addressing biological imbalances only once they become clinically manifest. Science …

Proactive Biology Cellular Resilience Signal Optimization
JENR Mini Review Feb 17, 2026
Epigenetic Sustainability: Modeling the Human Factor as a Natural Resource through Science 4.0 and the NR3C1 Biological Pilot
Boblique J*

The Anthropocene demands a paradigm shift in the management of natural resources. This paper introduces the concept of Epigenetic Sustainability, defining the human biological int…

Epigenetic Sustainability Science 4.0 Nr3c1
IZAB Perspective Jan 31, 2026
From SET Theory to Science 4.0: An AI-Driven Framework for Epigenetic Integrity and Biological Flow Control
Boblique J*

The transition to Science 4.0 represents a fundamental paradigm shift: moving from passive observation to the proactive navigation of biological flows. Building upon the Strategic…

Science 4.0 SET Theory NR3C1
IZAB Editorial Jan 7, 2026
A Social Epigenetic Theory of Systemic Transitions
Boblique J*

In high-stakes environments—such as air traffic control, emergency management, or complex logistics—the human operator is the central pivot of an uninterrupted flow of informati…

Systemic Transitions Traffic Control HPA