Medwin Publishers | Mario Valentino - Neurology & Neurotherapy Open Access Journal

Mario Valentino

Editorial Board Member

University of Malta Malta Member since 2017

Biography

Dr Valentino is Associate Professor in neuroscience. He obtained his Ph.D from the Max Planck Institute for Neurological Research, Cologne, Germany. His study involved the investigation of the haemodynamic and molecular mechanisms of ischemic brain damage caused by strokes. Subsequently, he was awarded a post-doctoral fellowship in the Dept. of Neurology, Washington University, St.Louis, MO, where he studied the neurobiology of white matter damage in the context of ischemia and hypoglycemia using advanced imaging techniques. At the University of Malta he established the Laboratory for the Study of Neurological Disorders that is centred around the study of mechanisms of injury and recovery after Stroke with special emphasis towards optical in vivo imaging and electrophysiology. He have shown that vulnerability of White Matter to ischemia varies during development and more recently that central axons preparing to myelinate are highly sensitive to ischemia and that axon metabolism resolves around astrocytic lactate. There is growing recognition that approaches to reducing injury must also protect the â€˜neurovascular unitâ€™. The dynamic events can at present be followed by high resolution imaging using multiphoton microscopy that enable us to capture cellular and molecular events deep down within brain structures. Knowledge of the intricate dynamics and cross-talk between neurons, glia and the vasculature is unraveling what causes these cells to die and how they could be made to recover.

Research Interests

Mechanisms of white matter injury Optical imaging Two-photon imaging Neonatal hypoxic ischemic encephalopathy neurovascular coupling

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Richa Tripathi

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Tamara C McGill Carter

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Rolando Xavier Aviles Reyes

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Faheem Hyder Pottoo

Imam Abdul Rahman Bin Faisal University

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Marco Orsini

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Neurology & Neurotherapy Open Access Journal

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