Alkhatib completed his Ph.D. in the Department of Microbiology and Immunology at McGill University, Montreal, Canada. His Ph.D. thesis included the first isolation of the cDNA encoding the morbillivirus envelope glycoprotein of measles virus. His postdoctoral experience in the Biotechnology Research institute in Montreal and the Mount Sinai Hospital Research Institute in Toronto provided him with additional background in gene expression and molecular immunology. His last postdoctoral training with Dr. Ed Berger at the laboratory of Viral Diseases, NIAID has resulted in the identification of CCR5 as the coreceptor for M-tropic strains of HIV-1.
He has been a Faculty member in the Department of Microbiology and Immunology at Indiana University School of Medicine for almost nine years. His research projects, funded by NIH, are focused on the mechanisms of retroviral entry into host cells. In particular, his laboratory recently identified the receptor for the human T cell leukemia virus type 1. His work in HIV research identified a host suppressive factor that inhibits the entry of a wide range of HIV-1 isolates. Dr. Alkhatib is also interested in the development of novel entry inhibitors that block retrovirus entry. His laboratory is actively investigating the anti-HIV activities of a chemokine-like protein encoded by a poxvirus. The major future goal of His research is related to translational research, which will lead to the production of biological compounds that block retrovirus infection.
molecular mechanisms involved in genetic resistance to HIV-1 infection. We focus on the molecular biology of viral entry by the human immunodeficiency virus type 1 (HIV-1) and the human T cell leukemia virus type 1 (HTLV-1). Additionally, we will investigate the mechanism of neurodegenerative disorders associated with HIV-1 and HTLV-1 infection.
Other Editorial Board Members
Eugene A Permyakov
Institute for Biological Instrumentation of the Russian Academy of Sciences
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