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Food Science & Nutrition Technology

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Adel Pezeshki

Associate Editor
Oklahoma State University USA Member since 2026

Research Interests

Liver plays an essential role in regulation of systemic glucose homeostasis. Hepatic insulin signaling is crucial for maintenance of normal glucose homeostasis through suppressing gluconeogenesis and promoting glycogenesis. Therefore, hepatic insulin resistance can contribute to hyperglycemia in type 2 diabetes. We have demonstrated that dietary branched-chain amino acids (BCAA) restriction improves glucose tolerance and insulin sensitivity, increases hepatic insulin signaling and suppresses gluconeogenesis in the liver [1, 2]. My laboratory is interested in unraveling the hepatic pathways that can define the compelling metabolic effects of dietary BCAA restriction by focusing on known and novel hepatokines.

Several proteins are predominantly and exclusively secreted by liver. These liver-derived proteins or hepatokines have some inconclusive roles in hepatic glucose metabolism and insulin signaling. My lab is focused on: 1) examining whether known or novel hepatokines are required for BCAA restriction-induced improvement in glucose metabolism and insulin signaling in the liver, 2) characterizing the pathways by which BCAA restriction induces these hepatokines, and 3) assessing the role of these hepatokines or new liver-derived factors in regulation of systemic glucose homeostasis when BCAA restricted diets are offered. To this end, our lab employs a variety of techniques such as genome editing in cell culture-based systems and animal models, and transcriptomics. The long-term goal of our program is to identify novel therapeutics for the treatment of diabetes.

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