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Genomics & Gene Therapy International Journal

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Ali Senejani

Ali Senejani

Editorial Board Member
University of New Haven USA Member since 2019

Biography

Ali Senejani is currently an Assistant Professor in the Department of Biology and Environmental Science at the University of New Haven. He has done his postdoctoral training working on DNA damage and repair in the department of genetics and therapeutic radiology at Yale University Medical School where he worked in the area of DNA damage and repair field. He constructed a knock-in mouse model expressing an impaired DNA repair gene and our results show there are several pathways and developmental stages that DNA repair genes significantly contribute to and these include: DNA repair base excision repair pathway, neurogenesis, meiosis, cancer, and immune development. His Ph.D. in genetics was completed in the department of molecular and cell biology at the University of Connecticut. His Ph.D. dissertation was focused on intein, homing endonuclease and the development of an in vivo selection system to evolve a novel restriction homing endonuclease enzyme; an enzyme that can recognize new large target sites to facilitate gene editing and repair of mutated genes. In brief, my specific research objective is to study gene-environment interaction, DNA damage and repair, and contribute to our understanding the correlation between aberrant DNA repair genes, mutagenesis, and their impacts on diseases such as cancer, neurodegenerative diseases and autoimmunity.

Research Interests

Cellular Biochemical and Molecular Genetic Aspects of DNA Repair Mutagenesis Cell Cycle Regulation Apoptosis Oxidative Stress and Level of DNA Damage

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