Mohammed Tarique is working as Post-doctoral Research Associate in the Parasite biology group at International Center for Genetic Engineering and Biotechnology, New Delhi. He did B.Sc. (Chemistry and Botany) in 2006 from Shibli National College, Azamgarh, UP and M.Sc. (Biotechnology) in 2008 from the department of biotechnology, Hamdard University, New Delhi, India. After completion of his M.Sc. program, he had joined the ICGEB, New Delhi as Pre-doctoral fellow and I focused my research on understanding the mismatch repair complex of malaria parasite. Their finding revealed many interesting facts about the MMR pathway and their associated components. They have characterized the first eukaryotic UvrD helicase from Plasmodium falciparum. He had also been part of the several research teams to study the Plasmodium falciparum DOZI (DDX6 Helicase), Plasmodium falciparum MLH, Werner (WRN) helicase, BLOOM (BLM) helicase, RuvB1 helicase, XPD helicase, XPB helicase, UvrD helicase, and several plant helicases like Oryza sativa BAT1, Oryza sativa SUV3 and Pisum sativum. Recently we focused to identify the inhibitor molecule of the helicases of therapeutic importance like UvrD helicase. Currently their work focused to identify the inhibitor molecule of PfMLH protein. Considering the previous and current finding about PfMLH and PfUvrD, it seems that targeting their interaction and or their biochemical activities may emerge as suitable therapeutic target for the control of malaria.
The proteins involved in DNA repair pathway of Plasmodium falciparum and to identify the novel inhibitors against these proteins.
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Anil Kumar Gaur
College of Basic Sciences and Humanities G. B. Pant University of Agriculture & Technology
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Sundip Kumar
College of Basic Sciences & Humanities, G. B. Pant University of Agriculture & Technology
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